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- Title
Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene.
- Authors
Lefebure, Marcus; Tothill, Richard W.; Kruse, Elizabeth; Hawkins, Edwin D.; Shortt, Jake; Matthews, Geoffrey M.; Gregory, Gareth P.; Martin, Benjamin P.; Kelly, Madison J.; Todorovski, Izabela; Doyle, Maria A.; Lupat, Richard; Li, Jason; Schroeder, Jan; Wall, Meaghan; Craig, Stuart; Poortinga, Gretchen; Cameron, Don; Bywater, Megan; Kats, Lev
- Abstract
The Eμ-Myc mouse is an extensively used model of MYC driven malignancy; however to date there has only been partial characterization of MYC co-operative mutations leading to spontaneous lymphomagenesis. Here we sequence spontaneously arising Eμ-Myc lymphomas to define transgene architecture, somatic mutations, and structural alterations. We identify frequent disruptive mutations in the PRC1-like component and BCL6-corepressor gene Bcor. Moreover, we find unexpected concomitant multigenic lesions involving Cdkn2a loss and other cancer genes including Nras, Kras and Bcor. These findings challenge the assumed two-hit model of Eμ-Myc lymphoma and demonstrate a functional in vivo role for Bcor in suppressing tumorigenesis.
- Publication
Nature Communications, 2017, Vol 8, Issue 3, p14581
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/ncomms14581