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- Title
FASES PRÉ-ANALÍTICA, ANALÍTICA E PÓS-ANALÍTICA NO MONITORAMENTO LABORATORIAL DA ANTICOAGULAÇÃO COM ANTAGONISTAS DA VITAMINA K.
- Authors
Michel Wolf, Jonas; Michel Wolf, Lucas
- Abstract
Thrombosis is a disease characterized by hypercoagulable events. Oral anticoagulant therapy with vitamin K antagonists (VKAs) is widely indicated for prevention and/or control of coagulation disorders. The administration of VKAs is difficult because of the complexity of dose setting. In general, individuals submitted to VKA therapy are monitored by prothrombin time, in which the degree of anticoagulation is assessed by the international normalized ratio. Invariably, the flow of laboratory processing, which comprises pre-analytical, analytical, and post-analytical phases, is of importance to the trustworthiness of results, with significant consequences to the medical practice. The purpose of this study was to carry out a review of the scientific literature using electronic databases to search for scientific materials, such as Google Scholar, MEDLINE, LILACS, PubMed, SciELO, and Science Direct. We discuss some aspects related to the analytical flow of laboratory monitoring in a clinical laboratory. In conclusion, appropriate management of the analytical phases is necessary so that therapeutic success using VKAs is possible.
- Publication
Clinical & Biomedical Research, 2017, Vol 37, Issue 2, p125
- ISSN
2357-9730
- Publication type
Article
- DOI
10.4322/2357-9730.70775