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- Title
Does gluten free diet have more implications than treatment of celiac disease?
- Authors
Talaie, Ramin
- Abstract
Aim: This study was aimed to evaluate symptomatic as well as histopathologic response to GFD in patients with gluten-sensitive enteropathies including celiac disease, lymphocytic duodenosis and non-specific duodenitis. Background: Gluten-free diet (GFD) is the main treatment of celiac disease. However, its impact on other disorders of gluten sensitivity spectrum is less clear. Patients and methods: In a prospective observational study in Modarres hospital Tehran, Iran, 35 patients with chronic manifestations including low BMI, diarrhea, greasy stool and bloating were evaluated using serology for anti-tTG, endoscopy and histopathology. Patients were categorized in three diagnostic groups accordingly including celiac disease (CD), lymphocytic doudenosis (LD) and non-specific duodenitis (NSD). All patients were put on a GFD for 6 months, and subjective symptomatic response, serology, endoscopy and histopathologic tests were repeated and compared with baselines and among groups. Results: Of the total 35 patients, 5 had CD (14.3%), 9 had LD (25.7%) and 21 (60%) had NSD. Bloating was the most common symptom followed by diarrhea. Majority of patients (80%) had low BMI. All symptoms alleviated following a GFD but bloating was the only significant one. A significant increase was found in total mean BMI (17.3±0.7 v.s. 17.9±0.9). Histopathologic examination showed a complete resolution in 48.5% (n=17) patients, 10 in NSD group, 4 in LD group and 3 in CD group. Final prevalence of gluten-sensitive enteropathy (LD and NSD cases that responded to GFD) was 46.6%. Conclusion: GFD may have more implications other than celiac disease. Other gluten-sensitive enteropathies, like LD and NSD, might also respond to this treatment particularly in patients with low BMI.
- Subjects
CELIAC disease diagnosis; CELIAC disease treatment; DIAGNOSIS of diarrhea; INTESTINAL disease diagnosis; DUODENUM; FECAL analysis; CELIAC disease; DEMOGRAPHY; ENDOSCOPY; GASTROENTEROLOGY; GLUTEN-free diet; LONGITUDINAL method; SCIENTIFIC observation; BODY mass index; TREATMENT effectiveness; SYMPTOMS; ANATOMY
- Publication
Gastroenterology & Hepatology from Bed to Bench, 2015, Vol 8, Issue 2, p160
- ISSN
2008-2258
- Publication type
Article