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- Title
In Vitro and in Vivo Study of Poly(Lactic-co-Glycolic) (PLGA)Membranes Treated with Oxygen Plasma and Coated with Nanostructured Hydroxyapatite Ultrathin Films for Guided Bone Regeneration Processes.
- Authors
Torres-Lagares, Daniel; Castellanos-Cosano, Lizett; Serrera-Figallo, María Ángeles; García-García, Francisco J.; López-Santos, Carmen; Barranco, Angel; Elipe, Agustín Rodríguez-Gonzalez; Rivera-Jiménez, Cristóbal; Gutiérrez-Pérez, José-Luis
- Abstract
The novelty of this study is the addition of an ultrathin layer of nanostructured hydroxyapatite (HA) on oxygen plasmamodified poly(lactic-co-glycolic) (PLGA)membranes (PO2) in order to evaluate the efficiency of this novel material in bone regeneration. Methods: Two groups of regenerative membranes were prepared: PLGA (control) and PLGA/PO2/HA (experimental). These membranes were subjected to cell cultures and then used to cover bone defects prepared on the skulls of eight experimental rabbits. Results: Cell morphology and adhesion of the osteoblasts to the membranes showed that the osteoblasts bound to PLGAwere smaller andwith a lower number of adhered cells than the osteoblasts bound to the PLGA/PO2/HA membrane (p < 0.05). The PLGA/PO2/HA membrane had a higher percentage of viable cells bound than the control membrane (p < 0.05). Both micro-CT and histological evaluation confirmed that PLGA/PO2/HA membranes enhance bone regeneration. A statistically significant difference in the percentage of osteoid area in relation to the total area between both groups was found. Conclusions: The incorporation of nanometric layers of nanostructured HA into PLGA membranes modified with PO2 might be considered for the regeneration of bone defects. PLGA/PO2/HA membranes promote higher osteosynthetic activity, new bone formation, and mineralisation than the PLGA control group.
- Subjects
POLYLACTIC acid; POLYMERIC membranes; HYDROXYAPATITE; THIN films; BONE regeneration
- Publication
Polymers (20734360), 2017, Vol 9, Issue 9, p410
- ISSN
2073-4360
- Publication type
Article
- DOI
10.3390/polym9090410