We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cordycepin Inhibits Enterovirus A71 Replication and Protects Host Cell from Virus-Induced Cytotoxicity through Adenosine Action Pathway.
- Authors
Lee, Yi-Ping; Yu, Chun-Keung; Wong, Tak-Wah; Chen, Li-Ching; Huang, Bu-Miin
- Abstract
Enterovirus A71 (EV-A71) infection typically causes mild illnesses, such as hand-foot-and-mouth disease (HFMD), but occasionally leads to severe or fatal neurological complications in infants and young children. Currently, there is no specific antiviral treatment available for EV-A71 infection. Thus, the development of an effective anti-EV-A71 drug is required urgently. Cordycepin, a major bioactive compound found in Cordyceps fungus, has been reported to possess antiviral activity. However, its specific activity against EV-A71 is unknown. In this study, the potency and role of cordycepin treatment on EV-A71 infection were investigated. Results demonstrated that cordycepin treatment significantly reduced the viral load and viral ribonucleic acid (RNA) level in EV-A71-infected Vero cells. In addition, EV-A71-mediated cytotoxicity was significantly inhibited in the presence of cordycepin in a dose-dependent manner. The protective effect can also be extended to Caco-2 intestinal cells, as evidenced by the higher median tissue culture infectious dose (TCID50) values in the cordycepin-treated groups. Furthermore, cordycepin inhibited EV-A71 replication by acting on the adenosine pathway at the post-infection stage. Taken together, our findings reveal that cordycepin could be a potential antiviral candidate for the treatment of EV-A71 infection.
- Subjects
CYTOTOXINS; BIOACTIVE compounds; ANTIVIRAL agents; RNA; DRUG efficacy; VIRAL load; TISSUE culture
- Publication
Viruses (1999-4915), 2024, Vol 16, Issue 3, p352
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v16030352