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- Title
Topical Anti-Inflammatory Activity of The Combination of Red Ginger Rhizome (Zingiber officinale var. rubrum), Red Betel Leaves (Piper crocatum Ruiz & Pav.), and Red Lemongrass (Cymbopogon nardus (L.) Rendle) Ethanolic Extracts.
- Authors
Charisma, Shintia Lintang; Putri, Fitriana Adelia; Prasuma, Galar Sigit; Ningrom, Ira Citra
- Abstract
The rhizome extracts of red ginger (Zingiber officinale var. rubrum), red betel leaves (Piper crocatum Ruiz & Pav.), and red lemon grass (Cymbopogon nardus (L.) Rendle) are traditionally used by Kebumen (Central Java, Indonesia) people to treat inflammation in osteoarthritis. This research aims to determine the topical anti-inflammatory activity of a combination of ethanol extracts from these three plants. The plant materials of each species were collected from Kebumen and extracted using the maceration method. The topical antiinflammatory activity was evaluated by the inflammation-associated edema method with a combination cream of 8% ethanol extract. The ratio of red ginger rhizome, red betel leaves, and red lemongrass were varied into four groups on a Biocream® basis. The thickness of the skin folds on the back of the mice was measured every 1 hour for up to 6 hours. The average percent decrease in inflammation from the positive control cream treatment groups 1, 2, 3, and 4 were 15.65%, -13.06%, 31.98%, -3.65%, and 31.29%. The data is not normally distributed with a p-value <0.05. Based on these results, it can be concluded that the combination of ethanol extract of red ginger rhizome, red betel leaf, and red lemon grass has the highest anti-inflammatory activity in group 2, with an average reduction in inflammation of 31.98% at the sixth hour.
- Subjects
ANTI-inflammatory agents; CYMBOPOGON; LEMONGRASS; DENDROBIUM; GINGER; EXTRACTS
- Publication
Current Trends in Biotechnology & Pharmacy, 2023, Vol 17, p100
- ISSN
0973-8916
- Publication type
Article