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- Title
Physiological regulation and metabolic role of browning in white adipose tissue.
- Authors
Jankovic, Aleksandra; Otasevic, Vesna; Stancic, Ana; Buzadzic, Biljana; Korac, Aleksandra; Korac, Bato
- Abstract
Great progress has been made in our understanding of the browning process in white adipose tissue (WAT) in rodents. The recognition that i) adult humans have physiologically inducible brown adipose tissue (BAT) that may facilitate resistance to obesity and ii) that adult human BAT molecularly and functionally resembles beige adipose tissue in rodents, reignited optimism that obesity and obesity-related diabetes type 2 can be battled by controlling the browning of WAT. In this review the main cellular mechanisms and molecular mediators of browning of WAT in different physiological states are summarized. The relevance of browning of WAT in metabolic health is considered primarily through a modulation of biological role of fat tissue in overall metabolic homeostasis.
- Subjects
WHITE adipose tissue; BROWN adipose tissue; METABOLISM; HOMEOSTASIS; DIABETES
- Publication
Hormone Molecular Biology & Clinical Investigation, 2017, Vol 31, Issue 1, p1
- ISSN
1868-1883
- Publication type
Article
- DOI
10.1515/hmbci-2017-0034