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- Title
Chasing the precursor of functional hematopoietic stem cells at the single cell levels in mouse embryos.
- Authors
Xiaochen Wang; Yuemin Gong; Hideo Ema
- Abstract
Background: Adult hematopoietic stem cells (HSCs), the ideal system for regenerative research, were isolated at single cell levels decades ago, whereas studies on embryonic HSCs are much more difficult. Methods: Zhou et al identified a new pre-HSC cell surface marker, CD201, by which they isolated pre-HSCs at single cell levels for further analyses. Results: The novel expression pattern of HSC development is revealed, including the fundamental role of mammalian targets of rapamycin (mTOR) signaling pathway in HSCs emergence, and the repopulation potential of S/G2/M phase pre-HSCs. Conclusions: Deeper understandings of the cellular origin and developmental regulatory network of HSCs are essential to develop new strategies of generating HSCs in vitro for clinical application.
- Subjects
HEMATOPOIETIC stem cells; GENE regulatory networks; EMBRYOS; RAPAMYCIN; CELL cycle
- Publication
Journal of Hematology & Oncology, 2016, Vol 9, p1
- ISSN
1756-8722
- Publication type
Article
- DOI
10.1186/s13045-016-0289-7