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- Title
Pre-operative systemic therapy in locally advanced breast cancer: a single institution experience.
- Authors
Ibrahim, E. M.; Al-Gahmi, A. M.; Zekri, J. M.; Awadalla, S. S.; Elkhodary, T. R.; Fawzy, E. E.; Bahadur, Y. A.; Elsayed, M. E.; Zeeneldin, A.; Al-Ahmadi, R. H.; Linjawi, A. H.
- Abstract
Background: Locally advanced breast cancer (LABC) is common in developing countries and it frequently affects younger women. Patients do very poorly when treated by locoregional therapy alone; therefore, pre-operative systemic therapy (PST) is commonly used. Materials and methods: Medical records of 64 Saudi patients with LABC treated with PST in a single institution were retrospectively reviewed. Results: At diagnosis, most patients were young (median age 41 years), and had poor clinicopathological characteristics. Following surgery, complete pathologic response (pCR) in the breast was achieved in 13 patients (20%). Of 62 patients with known nodal status, 22 (34%) had negative axillary nodes. Presence of oestrogen receptor (ER) negative tumour was the only dependent variable that predicted pCR in the breast (p = 0.03). At a median follow-up of 42 months, the median progression-free survival (PFS) was 48 months (95% CI, 20-76 months) and the projected five-year overall survival (OS) was 68%. The recently published scoring system (Jeruss et al (2008) J Clin Oncol 26 2 246-52), was the only variable that independently influenced PFS, while ER negative tumours and presence of lymphovascular space invasion were the only factors that adversely affected OS. Conclusions: despite the use of standard multi-modality approach in the management of patients with LABC, prognosis remains guarded.
- Subjects
SAUDI Arabia; BREAST cancer surgery; CANCER in women; PROGNOSIS; ESTROGEN; CANCER prognosis
- Publication
Ecancermedicalscience, 2009, Vol 3, p1
- ISSN
1754-6605
- Publication type
Article
- DOI
10.3332/ecancer.2009.161