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- Title
DETECÇÃO DE CITOCINA POR PCR EM TEMPO REAL NO TECIDO RENAL DE CAMUNDONGO INFECTADO COM LEISHMANIA (L) CHAGASI.
- Authors
Gonçalves de Oliveira, Elaine; Pereira Martins, Aline; Brenda, Georgia; Goto, Hiro; Lima Costa, Francisco Assis; das Graças Prianti, Maria
- Abstract
Visceral leishmaniasis (VL) is a serious chronic disease that affects humans and animals. Kidney changes is characterized by interstitial nephritis and glomerulonephritis (GN). There is evidence that inflammatory cytokines such as IL-1B, IL-4, may be involved in the pathogenesis of GN (MAIN et al. 1992). This study used BALB/c mice infected with amastigotes of L. chagasi in order to evaluate cytokines (IL-1B and IL-4) in the renal lesions . The results suggest that the cytokines IL-4 and IL-1B participate in the modulation of the immune response of the LV experimental glomerulonephritis in a murine model.
- Subjects
CYTOKINES; DIAGNOSTIC use of polymerase chain reaction; LEISHMANIA; LABORATORY mice; GLOMERULONEPHRITIS; INTERLEUKIN-4; VISCERAL leishmaniasis; KIDNEY diseases in animals
- Publication
Archives of Veterinary Science, 2013, Vol 18, Issue 3, p345
- ISSN
1517-784X
- Publication type
Article