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- Title
Interleukin‐4 cytokine single nucleotide polymorphisms in kawasaki disease: a case‐control study and a review of knowledge.
- Authors
Assari, Raheleh; Aghighi, Yahya; Ziaee, Vahid; Sadr, Maryam; Rezaei, Arezou; Rahmani, Farzaneh; Sadr, Zeinab; Raeeskarami, Seyed Reza; Moradinejad, Mohammad Hassan; Rezaei, Nima
- Abstract
Abstract: Aim: Kawasaki disease (KD) is a systemic vasculitis of medium‐sized arteries. High levels of interleukin 4 (IL‐4) and the dominance of Th2 cytokines seem to be a key feature in the acute phase of KD. In this study, the role of IL‐4 and IL‐4R gene polymorphisms were investigated in Iranian children with KD. Methods: Fifty‐five patients with KD and 140 healthy subjects as a control group were enrolled in this study. Single nucleotide polymorphisms (SNPs) of IL‐4 gene at positions −1098 (rs2243248), −590 (rs2243250) and −33 (rs2070874), as well as IL‐4RA gene at position +1902 (rs180275) were assessed in patients and the control group. Results: The C allele and CC genotype of IL‐4 gene at position −590 and at position −33 had positive associations and the CT genotype at −590 was negatively associated with KD (odds ratio (95% CI) = 0.04 [0.01–0.09]). The haplotype TCC was more frequent among the patients, while the haplotypes TTT and TTC had a negative association with KD. Conclusion: IL‐4 polymorphisms might be associated with KD in an Iranian population.
- Subjects
MUCOCUTANEOUS lymph node syndrome; INTERLEUKIN-4; SINGLE nucleotide polymorphisms; CYTOKINES; GENETIC polymorphisms
- Publication
International Journal of Rheumatic Diseases, 2018, Vol 21, Issue 1, p266
- ISSN
1756-1841
- Publication type
Article
- DOI
10.1111/1756-185X.12968