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- Title
Next-generation transgenic mice for optogenetic analysis of neural circuits.
- Authors
Asrican, Brent; Augustine, George J.; Berglund, Ken; Susu Chen; Nick Chow; Deisseroth, Karl; Guoping Feng; Gloss, Bernd; Riichiro Hira; Hoffmann, Carolin; Haruo Kasai; Katarya, Malvika; Jinsook Kim; Kudolo, John; Li Ming Lee; Shun Qiang Lo; Mancuso, James; Masanori Matsuzaki; Ryuichi Nakajima; Li Qiu
- Abstract
Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various neuron-specific promoters. These mice permit photoinhibition or photostimulation both in vitro and in vivo. Our results also reveal the important influence of fluorescent tags on optogenetic probe expression and function in transgenic mice.
- Subjects
TRANSGENIC animals; OPTOGENETICS; NEURAL circuitry; HALORHODOPSIN; RHODOPSIN; CEREBELLUM
- Publication
Frontiers in Neural Circuits, 2013, Vol 7, p1
- ISSN
1662-5110
- Publication type
Article
- DOI
10.3389/fncir.2013.00160