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- Title
Effect of Convalescent Plasma Therapy on Viral Shedding and Survival in Patients With Coronavirus Disease 2019.
- Authors
Zeng, Qing-Lei; Yu, Zu-Jiang; Gou, Jian-Jun; Li, Guang-Ming; Ma, Shu-Huan; Zhang, Guo-Fan; Xu, Jiang-Hai; Lin, Wan-Bao; Cui, Guang-Lin; Zhang, Min-Min; Li, Cheng; Wang, Ze-Shuai; Zhang, Zhi-Hao; Liu, Zhang-Suo
- Abstract
Currently, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been reported in almost all countries globally. No effective therapy has been documented for COVID-19, and the role of convalescent plasma therapy is unknown. In the current study, 6 patients with COVID-19 and respiratory failure received convalescent plasma a median of 21.5 days after viral shedding was first detected, all tested negative for SARS-CoV-2 RNA within 3 days after infusion, and 5 eventually died. In conclusion, convalescent plasma treatment can end SARS-CoV-2 shedding but cannot reduce the mortality rate in critically ill patients with end-stage COVID-19, and treatment should be initiated earlier.
- Subjects
CHINA; COVID-19; VIRAL shedding; SARS-CoV-2; CONVALESCENT plasma; CORONAVIRUS disease treatment; VIRAL pneumonia; VIRAL physiology; IMMUNIZATION; RNA; RETROSPECTIVE studies; CATASTROPHIC illness; TREATMENT effectiveness; EPIDEMICS; VIRAL antibodies; POLYMERASE chain reaction
- Publication
Journal of Infectious Diseases, 2020, Vol 221, p38
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiaa228