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- Title
Pan-Filovirus Serum Neutralizing Antibodies in a Subset of Congolese Ebolavirus Infection Survivors.
- Authors
Bramble, Matthew S; Hoff, Nicole; Gilchuk, Pavlo; Mukadi, Patrick; Lu, Kai; Doshi, Reena H; Steffen, Imke; Nicholson, Bradly P; Lipson, Allen; Vashist, Neerja; Sinai, Cyrus; Spencer, D'andre; Olinger, Garrard; Wemakoy, Emile Okitolonda; Illunga, Benoit Kebela; Pettitt, James; Logue, James; Marchand, Jonathan; Varughese, Justin; Bennett, Richard S
- Abstract
One year after a Zaire ebolavirus (EBOV) outbreak occurred in the Boende Health Zone of the Democratic Republic of the Congo during 2014, we sought to determine the breadth of immune response against diverse filoviruses including EBOV, Bundibugyo (BDBV), Sudan (SUDV), and Marburg (MARV) viruses. After assessing the 15 survivors, 5 individuals demonstrated some degree of reactivity to multiple ebolavirus species and, in some instances, Marburg virus. All 5 of these survivors had immunoreactivity to EBOV glycoprotein (GP) and EBOV VP40, and 4 had reactivity to EBOV nucleoprotein (NP). Three of these survivors showed serologic responses to the 3 species of ebolavirus GPs tested (EBOV, BDBV, SUDV). All 5 samples also exhibited ability to neutralize EBOV using live virus, in a plaque reduction neutralization test. Remarkably, 3 of these EBOV survivors had plasma antibody responses to MARV GP. In pseudovirus neutralization assays, serum antibodies from a subset of these survivors also neutralized EBOV, BDBV, SUDV, and Taï Forest virus as well as MARV. Collectively, these findings suggest that some survivors of naturally acquired ebolavirus infection mount not only a pan-ebolavirus response, but also in less frequent cases, a pan-filovirus neutralizing response.
- Subjects
EBOLA virus disease; EBOLA virus; EPIDEMICS; IMMUNE response; NUCLEOPROTEINS
- Publication
Journal of Infectious Diseases, 2018, Vol 218, Issue 12, p1929
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiy453