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- Title
Adaptation of Staphylococcus aureus to Airway Environments in Patients With Cystic Fibrosis by Upregulation of Superoxide Dismutase M and Iron-Scavenging Proteins.
- Authors
Treffon, Janina; Block, Desiree; Moche, Martin; Reiss, Swantje; Fuchs, Stephan; Engelmann, Susanne; Becher, Dörte; Langhanki, Lars; Mellmann, Alexander; Peters, Georg; Kahl, Barbara C.
- Abstract
Adaptation of S. aureus to the hostile environment of CF airways resulted in changed abundance of proteins involved in energy metabolism, cellular processes, transport and binding, but most importantly in an iron-scavenging phenotype and increased activity of superoxide dismutase M.
- Subjects
STAPHYLOCOCCUS aureus; AIRWAY (Anatomy); CYSTIC fibrosis; SUPEROXIDE dismutase; LUNG infections; IRON metabolism; RESPIRATORY organ microbiology; BACTERIAL protein metabolism; PHYSIOLOGICAL adaptation; BACTERIAL proteins; BIOCHEMISTRY; BIOLOGICAL transport; CARRIER proteins; COMPARATIVE studies; GENES; PHENOMENOLOGY; RESEARCH methodology; MEDICAL cooperation; RESEARCH; STAPHYLOCOCCAL diseases; EVALUATION research
- Publication
Journal of Infectious Diseases, 2018, Vol 217, Issue 9, p1453
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiy012