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- Title
High levels of Cellular Prion Protein improve astrocyte development
- Authors
Hartmann, Camila Arantes; Martins, Vilma Regina; Lima, Flavia Regina Souza
- Abstract
Abstract: Prion protein (PrPC) has neuroprotective functions and herein we demonstrate that astrocytes from PrPC-over-expressing mice are more resistant to induced cell death than wild-type astrocytes. The Stress-Inducible-Protein 1 (STI1), a PrPC ligand, prevents cell death in both wild-type and PrPC-over-expressing astrocytes through the activation of protein-kinase-A. Cultured embryonic astrocytes and brain extracts from PrPC-over-expressing mice show higher glial fibrillary acidic protein expression and reduced vimentin and nestin levels when compared to wild-type astrocytes, suggesting faster astrocyte maturation in the former mice. Our data indicate that PrPC levels modulate astrocyte development, and that PrPC–STI1 interaction contributes to protect against astrocyte death.
- Subjects
PRIONS; ASTROCYTES; NEUROPROTECTIVE agents; CELL death; VIMENTIN; GLIAL fibrillary acidic protein
- Publication
FEBS Letters, 2013, Vol 587, Issue 2, p238
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2012.11.032