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- Title
FXR signaling in metabolic disease
- Authors
Zhang, Yanqiao; Edwards, Peter A.
- Abstract
Abstract: Farnesoid X receptor (FXR), a member of the nuclear receptor superfamily, has been shown to be important in controlling numerous metabolic pathways; these include roles in maintaining bile acid, lipid and glucose homeostasis, in preventing intestinal bacterial infection and gallstone formation and in modulating liver regeneration and tumorigenesis. The accumulating data suggest that FXR may be a pharmaceutical target for the treatment of certain metabolic diseases.
- Subjects
NUCLEAR receptors (Biochemistry); METABOLIC disorders; BODY fluids; BACTERIAL diseases
- Publication
FEBS Letters, 2008, Vol 582, Issue 1, p10
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.11.015