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- Title
Current challenges in quantitative modeling of epidermal growth factor signaling
- Authors
Breitling, Rainer; Hoeller, Daniela
- Abstract
Abstract: Over the last decade, epidermal growth factor (EGF) signaling has been used repeatedly as a testbed for pioneering computational systems biology. Recent breakthroughs in our molecular understanding of EGF signaling pose new challenges for mathematical modeling strategies. Three key areas emerge as particularly relevant: the pervasive importance of compartmentalization and endosomal trafficking; the complexity of signalosome complexes; and the regulatory influence of diffusion and spatiality. Each one of them demands a drastic change in current computational approaches. We discuss recent developments in the field that address these emerging aspects in a new generation of more realistic – and potential more useful – models of EGF signaling.
- Subjects
EPIDERMAL growth factor; CYTOKINES; DIFFUSION; SOLUTION (Chemistry)
- Publication
FEBS Letters, 2005, Vol 579, Issue 28, p6289
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.10.034