We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Overexpression of proadrenomedullin N-terminal 20 peptide blunts blood pressure rise and attenuates myocardial hypertrophy and fibrosis in hypertensive rats
- Authors
Cao, Yuan-Ning; Kuwasako, Kenji; Kato, Johji; Nishihira, Kensaku; Asada, Yujiro; Eto, Tanenao; Kitamura, Kazuo
- Abstract
Abstract: We developed a transgenic (Tg) rat model that overexpresses human proadrenomedullin N-terminal 20 peptide (PAMP) only and then compared the effects of unilateral nephrectomy followed by a high salt diet for five weeks in Tg and wild-type rats. We found that systolic blood pressure was significantly lower in Tg UNX rats and cardiac hypertrophy and myocardial fibrosis was also attenuated in Tg rats. Evaluation of gene expression showed suppression of cardiac local renin-angiotensin system (RAS) in Tg rat. These results suggest that in addition to reducing blood pressure, PAMP suppresses cardiac hypertrophy through negative regulation of the local cardiac RAS.
- Subjects
CARDIAC hypertrophy; MURIDAE; PEPTIDE hormones; ADRENOMEDULLIN
- Publication
FEBS Letters, 2005, Vol 579, Issue 22, p4997
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.08.007