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- Title
Effect of n-3 fatty acids on markers of brain injury and incidence of sepsis-associated delirium in septic patients.
- Authors
BURKHART, C. S.; DELL‐KUSTER, S.; SIEGEMUND, M.; PARGGER, H.; MARSCH, S.; STREBEL, S. P.; STEINER, L. A.
- Abstract
Background Data regarding immunomodulatory effects of parenteral n-3 fatty acids in sepsis are conflicting. In this study, the effect of administration of parenteral n-3 fatty acids on markers of brain injury, incidence of sepsis-associated delirium, and inflammatory mediators in septic patients was investigated. Methods Fifty patients with sepsis were randomized to receive either 2 ml/kg/day of a lipid emulsion containing highly refined fish oil (equivalent to n-3 fatty acids 0.12 mg/kg/day) during 7 days after admission to the intensive care unit or standard treatment. Markers of brain injury and inflammatory mediators were measured on days 1, 2, 3 and 7. Assessment for sepsis-associated delirium was performed daily. The primary outcome was the difference in S-100β from baseline to peak level between both the intervention and the control group, compared by t-test. Changes of all markers over time were explored in both groups, fitting a generalized estimating equations model. Results Mean difference in change of S-100β from baseline to peak level was 0.34 (95% CI: −0.18-0.85) between the intervention and control group, respectively ( P = 0.19). We found no difference in plasma levels of S-100β, neuron-specific enolase, interleukin ( IL)-6, IL-8, IL-10, and C-reactive protein between groups over time. Incidence of sepsis-associated delirium was 75% in the intervention and 71% in the control groups (risk difference 4%, 95% CI −24-31%, P = 0.796). Conclusion Administration of n-3 fatty acids did not affect markers of brain injury, incidence of sepsis-associated delirium, and inflammatory mediators in septic patients.
- Subjects
THERAPEUTIC use of omega-3 fatty acids; BRAIN injuries; BIOMARKERS; SEPSIS; DELIRIUM
- Publication
Acta Anaesthesiologica Scandinavica, 2014, Vol 58, Issue 6, p689
- ISSN
0001-5172
- Publication type
Article
- DOI
10.1111/aas.12313