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- Title
Glucagon-Producing Cell Expansion in Wistar Rats. Changes to Islet Architecture After Sleeve Gastrectomy.
- Authors
Bancalero-delosReyes, José; Camacho-Ramírez, Alonso; Fernández-Vivero, José; Ribelles-García, Antonio; Macías-Rodríguez, Manuel; Almorza-Gomar, David; Carrasco-Molinillo, Carmen; Mayo-Ossorio, María Ángeles; Prada-Oliveira, José-Arturo; Perez-Arana, Gonzalo-Martín
- Abstract
Purpose: Many studies about bariatric surgery have analyzed the effect of sleeve gastrectomy (SG) on glucose improvement, beta-cell mass, and islet size modification. The effects of SG on the other endocrine cells of the pancreas, such as the alpha-cell population, and their regulatory mechanisms remain less studied. Materials and Methods: We focused our work on the changes in the alpha-cell population after SG in a healthy model of Wistar rats. We measured alpha-cell mass, glucose tolerance, and insulin release after oral glucose tolerance tests and plasma glucagon secretion patterns after insulin infusion. Three Wistar rat groups were employed: SG-operated, surgical control (Sham), and fasting control. Results: The results obtained showed significant increases in the alpha-cell population after SG. The result was an increase in beta-cell transdifferentiation; it was shown by some expressed molecules (the loss of expression of Pdx-1 and the increase in Arx and Pax6 cells/mm2 of islet). The serum results were enhanced plasma glucagon secretion pattern after insulin infusion assays and normal glucose tolerance and insulin release after OGTT. Conclusion: We concluded that SG leads to an expansion of the alpha-cell population, at expense of beta-cell; this expansion of alpha-cells is related to transdifferentiation. Plasma glucose level was not affected due to an increased glucagon response.
- Subjects
GLUCOSE tolerance tests; LABORATORY rats; SLEEVE gastrectomy; BLOOD sugar; ISLANDS; ISLANDS of Langerhans; GASTRIC inhibitory polypeptide
- Publication
Obesity Surgery, 2021, Vol 31, Issue 5, p2241
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-021-05264-6