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- Title
Serum leptin concentration in moderate and severe obesity: relationship with clinical, anthropometric and metabolic factors.
- Authors
Liuzzi, A; Savia, G; Tagliaferri, M; Lucantoni, R; Berselli, M E; Petroni, M L; De Medici, C; Viberti, G C
- Abstract
OBJECTIVE: To study clinical, anthropometric and metabolic determinants of serum leptin concentrations in a series of patients with a wide range of obesity. SUBJECTS: 400 patients, 116 males and 284 females, aged 44±12.3 years with body mass index (BMI) ranging from 31 to 82 kg/m² (mean 41.4±7.1). MEASUREMENTS: Energy intake by 7-day recall, resting energy expenditure (REE) by indirect calorimetry, body composition determined by bioelectrical impedance; C index, an anthropometric index of abdominal fat distribution, and waist-hip ratio (WHR), blood glucose serum leptin concentrations, total cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, uric acid, and insulin concentrations HOMA IRI (homeostastis model assessment of insulin resistance index). RESULTS: Leptin concentrations were higher in obese than in normal subjects and in females than in males without differences between diabetic and non-diabetic patients; leptin concentrations were not related to age and showed a strong negative association with energy intake only in the group of women with BMI less than 40. Leptin concentrations showed a direct correlation with BMI and body fat values (expressed either as percentage of total body mass or absolute fat mass) independent of age and sex. After adjustment for fat mass, leptin values higher than predicted were found in women whereas concentrations lower than predicted were found predominantly in men. Leptin showed an inverse correlation with WHR and C-index, the latter persisting also after correction for gender and fat mass. REE, but not REE/kg fat-free mass (FFM) was inversely related to leptin also after correction for sex and absolute fat mass. Leptin concentrations were directly associated with HOMA IRI, insulin and HDL cholesterol and inversely associated with triglycerides and uric acid. The relationship of leptin with HOMA IRI was still evident after adjusting for sex but was lost when absolute fat mass was...
- Subjects
LEPTIN; OBESITY; ANTHROPOMETRY; METABOLISM
- Publication
International Journal of Obesity & Related Metabolic Disorders, 1999, Vol 23, Issue 10, p1066
- ISSN
0307-0565
- Publication type
Article
- DOI
10.1038/sj.ijo.0801036