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- Title
Vaccination with β<sub>2</sub>-Microglobulin-Deficient Dendritic Cells Protects Against Growth of β<sub>2</sub>-Microglobulin-Deficient Tumours.
- Authors
Dammeyer, P.; Mwakigonja, A. R.; Rethi, B.; Chiodi, F.; Wolpert, E. Z.
- Abstract
Defects in cell surface expression of major histocompatibility complex class I antigen molecules are common in tumour cells. We have previously described the generation of adaptive immunity to tumour cells deficient in the transporter associated with antigen processing molecule. In this study, we demonstrate enhanced in vivo protection against growth of β2-microglobulin-deficient tumour cells in syngeneic C57Bl/6 mice, following vaccination with β2-microglobulin-deficient dendritic cells. In vitro analysis suggested that vaccinated mice produced CD3+ cells, which could induce apoptosis in syngeneic β2-microglobulin-deficient tumour and non-malignant cells. Further investigation of target cell recognition suggested that also tumour cells lacking expression of classical major histocompatibility complex class I heavy chains and functional transporter associated with antigen processing molecules were recognized by CD3+ effector cells from vaccinated mice. Histopathological examination of organs from vaccinated mice showed no significant vaccination-induced pathology. The present findings point to a new possible strategy to counteract the growth of major histocompatibility complex class I-deficient tumour cells.
- Subjects
DENDRITIC cells; VACCINATION; MAJOR histocompatibility complex genetics; PATHOLOGY; HLA histocompatibility antigens
- Publication
Scandinavian Journal of Immunology, 2009, Vol 70, Issue 1, p44
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.2009.02270.x