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- Title
Clinicopathologic evaluation of immunohistochemical E-cadherin expression in human gastric carcinomas.
- Authors
Shino, Yoshihide; Watanabe, Akihiko; Yamada, Yukishige; Tanase, Masahiro; Yamada, Takashi; Matsuda, Masahiko; Yatnashita, Jun; Tatsumi, Mitsutoshi; Miwa, Takeshi; Nakano, Hiroshige; Shino, Y; Watanabe, A; Yamada, Y; Tanase, M; Yamada, T; Matsuda, M; Yamashita, J; Tatsumi, M; Miwa, T; Nakano, H
- Abstract
<bold>Background: </bold>E-cadherin plays a crucial role in cell-cell adhesion in epithelial tissues. Recent studies have shown a correlation between decreased E-cadherin expression and cancer cell detachment.<bold>Methods: </bold>The expression of E-cadherin was immunohistochemically analyzed using antihuman E-cadherin antibody in 121 cases of human gastric carcinoma.<bold>Results: </bold>In noncancerous areas, the epithelial cells, including those with intestinal metaplasia, were stained positively in the plasma membrane. In contrast, E-cadherin expression of the cancer cells varied from case to case in primary and secondary sites. Tumors with a decrease in E-cadherin occurred significantly more frequently in undifferentiated adenocarcinoma (P < 0.05) and scirrhous type (P < 0.01). The rate of E-cadherin-negative tumors was higher in patients with peritoneal metastasis (P < 0.01) or in those with distant lymph node metastasis (P < 0.01), though the tumors with liver metastasis had relatively positive E-cadherin expression. Patterns of initial recurrence had similar results. Reduction or loss of E-cadherin expression correlated with shorter survival in patients after curative operation regardless of stage of disease.<bold>Conclusions: </bold>The decreased E-cadherin expression correlates with dedifferentiation, infiltrative tumor growth, distant metastasis, and poor survival for patients with gastric carcinoma. Thus, immunohistochemical study of E-cadherin may have clinicopathologic value for patients with gastric carcinoma.
- Publication
Cancer (0008543X), 1995, Vol 76, Issue 11, p2193
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19951201)76:11<2193::AID-CNCR2820761104>3.0.CO;2-2