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- Title
Local relapse and contralateral tumor rates in patients with breast cancer treated with conservative surgery and radiotherapy (Institut Gustave Roussy 1970-1982). IGR Breast Cancer Group.
- Authors
Dewar, John A.; Arriagada, Rodrigo; Benhamou, Simone; Benhamou, Ellen; Bretel, Jean-Jacques; Pellae-Cosset, Brigitte; Marin, Jean-Luc; Petit, Jean-Yves; Contesso, Geneviegve; Sarrazin, Daniegle; Dewar, J A; Arriagada, R; Benhamou, S; Benhamou, E; Bretel, J J; Pellae-Cosset, B; Marin, J L; Petit, J Y; Contesso, G; Sarrazin, D
- Abstract
<bold>Background: </bold>Breast conservation is now established treatment for patients with small breast cancers. The authors reviewed a large series of patients with long term follow-up who underwent conservative treatment. Clinical and pathologic factors were analyzed to identify patients at an increased risk of relapse in the breast (local relapse) or development of a contralateral tumor.<bold>Methods: </bold>Seven hundred fifty-seven patients with unilateral invasive breast cancer (T0-2, N0-1, M0) were treated conservatively (wide local excision and radiotherapy) at the Institut Gustave-Roussy between 1970 and 1982. The median follow-up was 9 years. The risk of local relapse or development of a contralateral tumor (as first event) was studied by univariate analysis for the main clinical, pathologic, and treatment factors. Those found to be significant were entered into a Cox proportional regression analysis.<bold>Results: </bold>Fifty-one patients relapsed in the treated breast (actuarial local relapse rates at 5 and 10 years were 5% and 8%, respectively) and 34 in the contralateral breast (actuarial contralateral tumor rates at 5 and 10 years were 3% and 6%, respectively). Multivariate analysis of the risk factors for local relapse showed that only age younger than 40 years (P < 0.02) or inadequate surgical excisioin (P < 0.02) were significant. No particular risk factors for contralateral tumor development were identified.<bold>Conclusions: </bold>Overall, for most patients, the risk of local relapse or of developing a contralateral tumor was low. A small number of young patients with inadequately excised tumors are at higher risk of local relapse, need more meticulous surgery, and may merit higher dose radiotherapy.
- Publication
Cancer (0008543X), 1995, Vol 76, Issue 11, p2260
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19951201)76:11<2260::AID-CNCR2820761113>3.0.CO;2-D