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- Title
Experimental Infection of Human Volunteers with Haemophilus ducreyi: Fifteen Years of Clinical Data and Experience.
- Authors
Janowicz, Diane M.; Ofner, Susan; Katz, Barry P.; Spinola, Stanley M.
- Abstract
Haemophilus ducreyi causes chancroid, which facilitates transmission of human immunodeficiency virus type 1. To better understand the biology of H. ducreyi, we developed a human inoculation model. In the present article, we describe clinical outcomes for 267 volunteers who were infected with H. ducreyi. There was a relationship between papule formation and estimated delivered dose. The outcome (either pustule formation or resolution) of infected sites for a given subject was not independent; the most important determinants of pustule formation were sex and host effects. When 41 subjects were infected a second time, their outcomes segregated toward their initial outcome, confirming the host effect. Subjects with pustules developed local symptoms that required withdrawal from the study after a mean of 8.6 days. There were 191 volunteers who had tissue biopsy performed, 173 of whom were available for follow-up analysis; 28 (16.2%) of these developed hypertrophic scars, but the model was otherwise safe. Mutant-parent trials confirmed key features in H. ducreyi pathogenesis, and the model has provided an opportunity to study differential human susceptibility to a bacterial infection.
- Subjects
HAEMOPHILUS ducreyi; CHANCROID; HAEMOPHILUS diseases; HIV; HIV virus enzymes; MALIGNANT pustule; HYPERTROPHIC scars; DIAGNOSIS of bacterial diseases; SEXUALLY transmitted disease risk factors; DIAGNOSIS
- Publication
Journal of Infectious Diseases, 2009, Vol 199, Issue 11, p1671
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/598966