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- Title
D-dimer and CA 125 levels in patients with ovarian cancer during antineoplastic therapy. Prognostic significance for the success of anti-cancer treatment.
- Authors
Mirshahi, S. S.; Pujade-Lauraine, E.; Soria, C.; Mirshahi, M.; Fretault, J.; Bernadou, A.; Soria, J.
- Abstract
In patients with ovarian cancer before they receive chemotherapy, the level of fibrin degradation products (D-dimer), is correlated with the tumor load. In this study, the evolution of D-dimer was compared in patients receiving antineoplastic therapy with the evolution of the disease. The patients could be classified into three groups. In Group 1 (nine patients), both plasma CA 125 (a tumor-associated antigen) and D-dimer remained elevated; the prognosis was always poor. In Group 2 (eight patients), CA 125 and D-dimer decreased simultaneously, complete remission was observed in two patients, and significant residual tumor was observed in the others. In Group 3 (nine patients), despite an important decrease in CA 125, D-dimer remained elevated during therapy. In this group, complete remission was observed in six patients, and three others showed a large decrease in their tumor load. The combination of a decrease in CA 125 levels with a continuous enhanced level of D-dimer during chemotherapy identified a subgroup of patients with a favorable prognosis.
- Publication
Cancer (0008543X), 1992, Vol 69, Issue 9, p2289
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19920501)69:9<2289::AID-CNCR2820690914>3.0.CO;2-A