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- Title
Expression of the multidrug transporter, P-glycoprotein, in acute leukemia cells and correlation to clinical drug resistance.
- Authors
Kuwazuru, Yasuo; Yoshimura, Akihiko; Hanada, Shuichi; Utsunomiya, Atae; Makino, Torahiko; Ishibashi, Kazuaki; Kodama, Masahiko; Iwahashi, Masato; Arima, Terukatsu; Akiyama, Shin-Ichi; Kuwazuru, Y; Yoshimura, A; Hanada, S; Utsunomiya, A; Makino, T; Ishibashi, K; Kodama, M; Iwahashi, M; Arima, T; Akiyama, S
- Abstract
The overexpression of a cell-surface glycoprotein termed P-glycoprotein (P-gp) is frequently associated with multi-drug resistance (MDR) in cell lines in vitro. To evaluate the implications of P-gp expression in clinical drug resistance, the authors examined the expression of P-gp in leukemia cells from patients with acute myelogenous leukemia (AML) and those with acute lymphoblastic leukemia (ALL) at initial presentation and relapse, using immunoblotting with a monoclonal antibody against P-gp, C219. Nine of 17 patients with AML and four of 11 patients with ALL had P-gp-positive results at the initial presentation, and most P-gp-positive patients did not respond to chemotherapy. Four of seven patients at the relapsed stage and all three patients with preceding myelodysplastic syndrome had P-gp-positive results. The expression of P-gp and clinical refractoriness to chemotherapy were highly correlated. These data indicate that the expression of P-gp is closely related to clinical drug resistance in acute leukemia.
- Publication
Cancer (0008543X), 1990, Vol 66, Issue 5, p868
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19900901)66:5<868::AID-CNCR2820660510>3.0.CO;2-Z