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- Title
Class I HLA-A*7401 Is Associated with Protection from HIV-1 Acquisition and Disease Progression in Mbeya, Tanzania.
- Authors
Koehler, Rebecca N.; Walsh, Anne M.; Saathoff, Elmar; Tovanabutra, Sodsai; Arroyo, Miguel A.; Currier, Jeffery R.; Maboko, Leonard; Hoelsher, Michael; Robb, Merlin L.; Michael, Nelson L.; McCutchan, Francine E.; Kim, Jerome H.; Kijak, Gustavo H.
- Abstract
Here we explore associations between HLA variation and human immunodeficiency virus type 1 (HIV-1) acquisition and disease progression in a community cohort in Mbeya, Tanzania, a region that, despite harboring high rates of HIV-1 infection, remains understudied. African-specific allele HLA-A*74:01 was associated with decreased risk of infection (odds ratio [OR], 0.37; 95% confidence interval [CI], 0.14-0.80; P=.011) and with protection from CD4+ cell counts <200 cells/uL in women (OR, 0.31; 95% CI, 0.07-0.91; P=.032) and men (OR, 0.15; 95% CI, 0.01-0.78; P=.020). These associations remained significant after adjustment for linkage disequilibrium with HLA-B and HLA-C alleles. This observation calls for additional investigation of mechanisms by which HLA-A*74:01 may influence HIV-1 acquisition and control of the infection.
- Subjects
MBEYA (Tanzania); TANZANIA; HLA histocompatibility antigens; HIV infections; HIV; GENE frequency
- Publication
Journal of Infectious Diseases, 2010, Vol 202, Issue 10, p1562
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/656913