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- Title
On the Cytoadhesion of Plasmodium vivax-Infected Erythrocytes.
- Authors
Bruna O. Carvalho; Lopes, Stefanie C. P.; Nogueira, Paulo A.; Orlandi, Patricia P.; Bargieri, Daniel Y.; Blanco, Yara C.; Mamoni, Ronei; Leite, Juliana A.; Rodrigues, Mauricio M.; Soares, Irene S.; Oliveira, Tatiane R.; Wunderlich, Gerhard; Lacerda, Marcus V. G.; del Portillo, Hernando A.; Maria O. G. Araüjo; Russell, Bruce; Suwanarusk, Rossarin; Snounou, Georges; Rénia, Laurent; Costa, Fabio T. M.
- Abstract
Background. Plasmodium falciparum and Plasmodium vivax are responsible for most of the global burden of malaria. Although the accentuated pathogenicity of P falciparum occurs because of sequestration of the mature erythrocytic forms in the microvasculature, this phenomenon has not yet been noted in P vivax. The increasing number of severe manifestations of P vivax infections, similar to those observed for severe falciparum malaria, suggests that key pathogenic mechanisms (eg, cytoadherence) might be shared by the 2 parasites. Methods. Mature P. vivax-infected erythrocytes (Pv-iEs) were isolated from blood samples collected from 34 infected patients. Pv-iEs enriched on Percoll gradients were used in cytoadhesion assays with human lung endothelial cells, Saimiri brain endothelial cells, and placental cryosections, Results. Pv-iEs were able to cytoadhere under static and flow conditions to cells expressing endothelial receptors known to mediate the cytoadhesion of P falciparurn. Although Pv-iE cytoadhesion levels were 10-fold lower than those observed for P falciparum-infected erythrocytes, the strength of the interaction was similar. Cytoadhesion of Pv-iEs was in part mediated by VIR proteins, encoded by P. vivax variant genes (vir), given that specific antisera inhibited the Pv-iE-endothelial cell interaction. Conclusions. These observations prompt a modification of the current paradigms of the pathogenesis of malaria and clear the way to investigate the pathophysiology of P. vivax infections.
- Subjects
PLASMODIUM falciparum; PLASMODIUM vivax; MALARIA; PATHOGENIC microorganisms; PATHOLOGICAL physiology; IMMUNE serums; ERYTHROCYTES; CELL communication; BLOOD cells
- Publication
Journal of Infectious Diseases, 2010, Vol 202, Issue 4, p638
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/654815