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- Title
Marine-Inspired Drugs and Biomaterials in the Perspective of Pancreatic Cancer Therapies.
- Authors
Fernandes, Andreia S.; Oliveira, Catarina; Reis, Rui L.; Martins, Albino; Silva, Tiago H.
- Abstract
Despite its low prevalence, pancreatic cancer (PC) is one of the deadliest, typically characterised as silent in early stages and with a dramatically poor prognosis when in its advanced stages, commonly associated with a high degree of metastasis. Many efforts have been made in pursuing innovative therapeutical approaches, from the search for new cytotoxic drugs and other bioactive compounds, to the development of more targeted approaches, including improved drug delivery devices. Marine biotechnology has been contributing to this quest by providing new chemical leads and materials originating from different organisms. In this review, marine biodiscovery for PC is addressed, particularly regarding marine invertebrates (namely sponges, molluscs, and bryozoans), seaweeds, fungi, and bacteria. In addition, the development of biomaterials based on marine-originating compounds, particularly chitosan, fucoidan, and alginate, for the production of advanced cancer therapies, is also discussed. The key role that drug delivery can play in new cancer treatments is highlighted, as therapeutical outcomes need to be improved to give further hope to patients.
- Subjects
PANCREATIC cancer; DRUG delivery devices; BIOMATERIALS; CANCER treatment; MARINE biotechnology; MARINE invertebrates
- Publication
Marine Drugs, 2022, Vol 20, Issue 11, p689
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md20110689