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- Title
Laucysteinamide A, a Hybrid PKS/NRPS Metabolite from a Saipan Cyanobacterium, cf. Caldora penicillata.
- Authors
Chen Zhang; Naman, C. Benjamin; Engene, Niclas; Gerwick, William H.
- Abstract
A bioactivity guided study of a cf. Caldora penicillata species, collected during a 2013 expedition to the Pacific island of Saipan, Northern Mariana Islands (a commonwealth of the USA), led to the isolation of a new thiazoline-containing alkaloid, laucysteinamide A (1). Laucysteinamide A is a new monomeric analogue of the marine cyanobacterial metabolite, somocystinamide A (2), a disulfide-bonded dimeric compound that was isolated previously from a Fijian marine cyanobacterium. The structure and absolute configuration of laucysteinamide A (1) was determined by a detailed analysis of its NMR, MS, and CD spectra. In addition, the highly bioactive lipid, curacin D (3), was also found to be present in this cyanobacterial extract. The latter compound was responsible for the potent cytotoxicity of this extract to H-460 human non-small cell lung cancer cells in vitro.
- Subjects
MARINE metabolites; NON-small-cell lung carcinoma; LUNG cancer treatment; MARINE natural products; THIAZOLINES; ALKALOIDS
- Publication
Marine Drugs, 2017, Vol 15, Issue 4, p121
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md15040121