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- Title
LLIN evaluation in Uganda project (LLINEUP2): association between housing construction and malaria burden in 32 districts.
- Authors
Gonahasa, Samuel; Nassali, Martha; Maiteki‑Sebuguzi, Catherine; Namuganga, Jane F.; Opigo, Jimmy; Nabende, Isaiah; Okiring, Jaffer; Epstein, Adrienne; Snyman, Katherine; Nankabirwa, Joaniter I.; Kamya, Moses R.; Dorsey, Grant; Staedke, Sarah G.
- Abstract
Background: Well-built housing limits mosquito entry and can reduce malaria transmission. The association between community-level housing and malaria burden in Uganda was assessed using data from randomly selected households near 64 health facilities in 32 districts. Methods: Houses were classified as 'improved' (synthetic walls and roofs, eaves closed or absent) or 'less-improved' (all other construction). Associations between housing and parasitaemia were made using mixed effects logistic regression (individual-level) and multivariable fractional response logistic regression (community-level), and between housing and malaria incidence using multivariable Poisson regression. Results: Between November 2021 and March 2022, 4.893 children aged 2–10 years were enrolled from 3.518 houses; of these, 1.389 (39.5%) were classified as improved. Children living in improved houses had 58% lower odds (adjusted odds ratio = 0.42, 95% CI 0.33–0.53, p < 0.0001) of parasitaemia than children living in less-improved houses. Communities with > 67% of houses improved had a 63% lower parasite prevalence (adjusted prevalence ratio 0.37, 95% CI 0.19–0.70, p < 0.0021) and 60% lower malaria incidence (adjusted incidence rate ratio 0.40, 95% CI 0.36–0.44, p < 0.0001) compared to communities with < 39% of houses improved. Conclusions: Improved housing was strongly associated with lower malaria burden across a range of settings in Uganda and should be utilized for malaria control.
- Subjects
UGANDA; HOUSE construction; MALARIA; PROJECT evaluation; POISSON regression; MALARIA prevention
- Publication
Malaria Journal, 2024, Vol 23, Issue 1, p1
- ISSN
1475-2875
- Publication type
Article
- DOI
10.1186/s12936-024-05012-y