We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The regulatory effect of zinc on the association between periodontitis and atherosclerotic cardiovascular disease: a cross-sectional study based on the National Health and Nutrition Examination Survey.
- Authors
Yang, Xiuxiu; Luo, Maoyu; Jiang, Yao
- Abstract
Background: Zinc has been proven to be effective against periodontitis, and also reported to reduce the risk of cardiovascular diseases (CVD). This study aims to explore the regulatory effect of zinc intake on the association between periodontitis and atherosclerotic cardiovascular disease (ASCVD). Methods: This was a cross-sectional study based on the National Health and Nutrition Examination Survey (NHANES). Logistic regression model was used to explore the association between zinc-RDA or periodontitis and 10-year ASCVD risk ≥ 20%, and results were shown as odds ratio (OR) and 95% confidence interval (95% CI). The regulatory effect of zinc intake on the association between periodontitis and 10-year ASCVD risk ≥ 20% was also assessed using logistic regression model. Subgroup analysis was performed based on age, gender, obesity, education level, lipid-lowering therapy, and dental floss. Results: 6,075 patients were finally included for analysis. Zinc intake reaching the recommended level (OR = 0.82, 95%CI: 0.69–0.98) and periodontitis (OR = 2.47, 95%CI: 2.04-3.00) were found to be associated with 0.82-fold and 2.47-fold odds of 10-year ASCVD risk ≥ 20%, respectively. In addition, we found that the odds of 10-year ASCVD risk ≥ 20% was lower in patients with zinc intake reaching the recommended level than those without [OR (95%CI): 2.25 (1.81–2.80) vs. 2.72 (2.05–3.62)]. The similar regulatory effect was found in patients with age ≥ 60 years and < 60 years, in male and female, with or without obesity, in different education levels, with or without lipid lowering therapy, and with or without use of dental floss (all P < 0.05). Conclusions: This study found the regulatory effect of adequate zinc intake on the association between periodontitis and ASCVD, providing guidance for periodontitis patients to decrease the risk of ASCVD.
- Subjects
ATHEROSCLEROSIS prevention; ATHEROSCLEROSIS risk factors; RISK assessment; CROSS-sectional method; STATISTICAL models; HDL cholesterol; ANTILIPEMIC agents; T-test (Statistics); FOOD consumption; BODY mass index; EXERCISE; GLYCOSYLATED hemoglobin; QUESTIONNAIRES; LOGISTIC regression analysis; SEX distribution; INTERVIEWING; MULTIPLE regression analysis; SMOKING; NUTRITIONAL requirements; ZINC; DESCRIPTIVE statistics; AGE distribution; CHI-squared test; HYPOGLYCEMIC agents; ANTIHYPERTENSIVE agents; ORAL hygiene; SURVEYS; ODDS ratio; DENTAL floss; RACE; ANALYSIS of variance; CONFIDENCE intervals; COMPARATIVE studies; DATA analysis software; ALCOHOL drinking; DENTAL caries; DIETARY carbohydrates; PERIODONTITIS; OBESITY; EDUCATIONAL attainment; DIETARY supplements; DIABETES; DISEASE complications
- Publication
BMC Oral Health, 2024, Vol 24, Issue 1, p1
- ISSN
1472-6831
- Publication type
Article
- DOI
10.1186/s12903-024-04473-6