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- Title
Fulminant arterial vasculitis as an unusual complication of disseminated staphylococcal disease due to the emerging CC1 methicillin-susceptible Staphylococcus aureus clone: a case report.
- Authors
Vidal, Charles; Moulin, Florence; Nassif, Xavier; Galmiche, Louise; Borgel, Delphine; Charbit, Alain; Picard, Capucine; Mira, Jean-Paul; Lortholary, Olivier; Jamet, Anne; Toubiana, Julie
- Abstract
<bold>Background: </bold>Staphylococcus aureus has emerged as a leading cause of invasive severe diseases with a high rate of morbidity and mortality worldwide. The wide spectrum of clinical manifestations and outcome observed in staphylococcal illness may be a consequence of both microbial factors and variability of the host immune response.<bold>Case Presentation: </bold>A 14-years old child developed limb ischemia with gangrene following S. aureus bloodstream infection. Histopathology revealed medium-sized arterial vasculitis. The causing strain belonged to the emerging clone CC1-MSSA and numerous pathogenesis-related genes were identified. Patient's genotyping revealed functional variants associated with severe infections. A combination of virulence and host factors might explain this unique severe form of staphylococcal disease.<bold>Conclusion: </bold>A combination of virulence and genetic host factors might explain this unique severe form of staphylococcal disease.
- Subjects
STAPHYLOCOCCAL diseases; STAPHYLOCOCCUS aureus; GANGRENE; MOLECULAR cloning; VASCULITIS; IMMUNE response; ANTIBIOTICS; LEG surgery; AMPUTATION; BRAIN; CEFOTAXIME; CLINDAMYCIN; MAGNETIC resonance imaging; METHICILLIN; SEPTIC shock; DISEASE complications; PHARMACODYNAMICS
- Publication
BMC Infectious Diseases, 2019, Vol 19, Issue 1, pN.PAG
- ISSN
1471-2334
- Publication type
journal article
- DOI
10.1186/s12879-019-3933-3