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- Title
Inflammatory biomarkers in cardiac syndrome X: a systematic review and meta-analysis.
- Authors
Zhao, Yuexia; Ghaedi, Arshin; Azami, Pouria; Nabipoorashrafi, Seyed Ali; Drissi, Hamed Bazrafshan; Dezfouli, Maryam Amin; Sarejloo, Shirin; Lucke-Wold, Brandon; Cerillo, John; Khanzadeh, Monireh; Jafari, Negar; Khanzadeh, Shokoufeh
- Abstract
Introduction: In the current systematic review and meta-analysis, we aim to analyze the existing literature to evaluate the role of inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein (CRP), tumor necrosis factor-a (TNF-a), and interleukin-6 (IL-6) among individuals with cardiac syndrome X (CSX) compared to healthy controls. Methods: We used PubMed, Web of Science, Scopus, Science Direct, and Embase to systematically search relevant publications published before April 2, 2023. We performed the meta-analysis using Stata 11.2 software (Stata Corp, College Station, TX). So, we used standardized mean difference (SMD) with a 95% confidence interval (CI) to compare the biomarker level between patients and healthy controls. The I2 and Cochran's Q tests were adopted to determine the heterogeneity of the included studies. Results: Overall, 29 articles with 3480 participants (1855 with CSX and 1625 healthy controls) were included in the analysis. There was a significantly higher level of NLR (SMD = 0.85, 95%CI = 0.55–1.15, I2 = 89.0 %), CRP (SMD = 0.69, 95%CI = 0.38 to 1.02, p < 0.0001), IL-6 (SMD = 5.70, 95%CI = 1.91 to 9.50, p = 0.003), TNF-a (SMD = 3.78, 95%CI = 0.63 to 6.92, p = 0.019), and PLR (SMD = 1.38, 95%CI = 0.50 to 2.28, p = 0.02) in the CSX group in comparison with healthy controls. Conclusion: The results of this study showed that CSX leads to a significant increase in inflammatory biomarkers, including NLR, CRP, IL-6, TNF-a, and PLR.
- Subjects
COLLEGE Station (Tex.); PLATELET lymphocyte ratio; NEUTROPHIL lymphocyte ratio; BIOMARKERS; C-reactive protein; SYNDROMES
- Publication
BMC Cardiovascular Disorders, 2024, Vol 24, Issue 1, p1
- ISSN
1471-2261
- Publication type
Article
- DOI
10.1186/s12872-024-03939-3