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- Title
IL-1β promotes adipogenesis by directly targeting adipocyte precursors.
- Authors
Hofwimmer, Kaisa; de Paula Souza, Joyce; Subramanian, Narmadha; Vujičić, Milica; Rachid, Leila; Méreau, Hélène; Zhao, Cheng; Dror, Erez; Barreby, Emelie; Björkström, Niklas K.; Wernstedt Asterholm, Ingrid; Böni-Schnetzler, Marianne; Meier, Daniel T.; Donath, Marc Y.; Laurencikiene, Jurga
- Abstract
Postprandial IL-1β surges are predominant in the white adipose tissue (WAT), but its consequences are unknown. Here, we investigate the role of IL-1β in WAT energy storage and show that adipocyte-specific deletion of IL-1 receptor 1 (IL1R1) has no metabolic consequences, whereas ubiquitous lack of IL1R1 reduces body weight, WAT mass, and adipocyte formation in mice. Among all major WAT-resident cell types, progenitors express the highest IL1R1 levels. In vitro, IL-1β potently promotes adipogenesis in murine and human adipose-derived stem cells. This effect is exclusive to early-differentiation-stage cells, in which the adipogenic transcription factors C/EBPδ and C/EBPβ are rapidly upregulated by IL-1β and enriched near important adipogenic genes. The pro-adipogenic, but not pro-inflammatory effect of IL-1β is potentiated by acute treatment and blocked by chronic exposure. Thus, we propose that transient postprandial IL-1β surges regulate WAT remodeling by promoting adipogenesis, whereas chronically elevated IL-1β levels in obesity blunts this physiological function. The consequences of postprandial IL-1β surges in white adipose tissue are unknown. Here the authors show IL-1β regulates WAT remodelling by promoting adipogenesis and energy storage, which is blocked by chronic elevation of this cytokine (as in obesity).
- Subjects
WHITE adipose tissue; HUMAN stem cells; BODY weight; WEIGHT loss; ADIPOGENESIS; ENERGY storage
- Publication
Nature Communications, 2024, Vol 15, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-024-51938-x