We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Fibrinogen-to-platelet ratio as a predictor of COVID-19 outcomes in non-diabetic patients.
- Authors
Reyes-Ruiz, José Manuel; Ríos-Ríos, Monserratte; Martínez-Mier, Gustavo; Sánchez-Díaz, Jesús Salvador; De Jesús-González, Luis Adrián; Osuna-Ramos, Juan Fidel; Ramos-Hernández, Wendy Marilú; Peniche Moguel, Karla Gabriela; Ordoñez-Rodríguez, Tatiana
- Abstract
The fibrinogen-platelet ratio (FPR) is used to identify patients likely to develop thrombotic complications. COVID-19 mortality is associated with venous thromboembolism. The objective of this study was to evaluate the prognostic value of FPR as a coagulative index by examining survival in non-diabetics patients with COVID-19. This is a retrospective single-center observational study conducted at a tertiary care hospital to determine the prognostic role of FPR. Clinical predictors were identified using Cox proportional hazard regression models to calculate the hazard ratio (HR) with a corresponding 95 % confidence interval (CI). Receiver Operator Characteristic (ROC) curve and Kaplan-Meier curve were calculated. Non-survival group had higher FPR (P < 0.0001) levels in comparison with the survival group. Cox analysis showed that FPR (HR = 3.525, 95 % CI 1.191-10.431; P = 0.022) was an independent high-risk factor associated with COVID-19 mortality in non-diabetic patients. The area under the curve (AUC) of FPR was 0.715 (P = 0.001) with 72 % sensitivity and 62.22 % specificity. Patients admitted to the hospital with a lower FPR [< 34.2] had significantly longer overall survival compared to a higher FPR [> 34.2] (P = 0.002). In this study was suggested that FPR > 34.2 on admission could effectively predict COVID-19 mortality in non-diabetic patients.
- Subjects
FIBRINOGEN; BLOOD platelets; CORONAVIRUS diseases
- Publication
Veterinaria México OA, 2024, Vol 11, p86
- ISSN
2448-6760
- Publication type
Abstract
- DOI
10.22201/fmvz.24486760e.2024.1305