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- Title
Regulation of Energy and Glucose Homeostasis by the Nucleus of the Solitary Tract and the Area Postrema.
- Authors
Bruce, Kyla; Garrido, Ameth N.; Song-Yang Zhang; Lam, Tony K. T.
- Abstract
The central nervous system regulates feeding, weight and glucose homeostasis in rodents and humans, but the site-specific mechanisms remain unclear. The dorsal vagal complex in the brainstem that contains the nucleus of the solitary tract (NTS) and area postrema (AP) emerges as a regulatory center that impacts energy and glucose balance by monitoring hormonal and nutrient changes. However, the specific mechanistic metabolic roles of the NTS and AP remain elusive. This mini-review highlights methods to study their distinct roles and recent findings on their metabolic differences and similarities of growth differentiation factor 15 (GDF15) action and glucose sensing in the NTS and AP. In summary, future research aims to characterize hormonal and glucose sensing mechanisms in the AP and/or NTS carries potential to unveil novel targets that lower weight and glucose levels in obesity and diabetes.
- Subjects
SOLITARY nucleus; GROWTH differentiation factors; CENTRAL nervous system; ENERGY metabolism; GLUCOSE metabolism
- Publication
Endocrinology & Metabolism, 2024, Vol 39, Issue 4, p559
- ISSN
2093-596X
- Publication type
Article
- DOI
10.3803/EnM.2024.2025