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- Title
Synthesis of New A-Seco-Derivatives of Methyl Glycyrrhetinate.
- Authors
Karimova, E. R.; Baltina, L. A.; Nugumanov, T. R.; Medvedeva, N. I.; Spirikhin, L. V.; Kukovinets, O. S.
- Abstract
New A-seco-derivatives of methyl glycyrrhetinate (MeGLC) were synthesized. Cleavage of ring A of the 2-hydroxymethylene-3-oxo-derivative of MeGLC by H2O2 (30%) in the presence of NaOMe (28%) in MeOH led to the 2,3-seco-2,3-diacid, which was isolated as the dimethyl ester. Ozonolysis of the 2-hydroxymethylene-3-oxo-derivative of MeGLC produced for the first time the methyl esters of 2,3-seco-2-ethoxycarbonyl- 18βH-olean-12-ene-2,3,30-trioic acid and 2,3-anhydro-11-oxo-18βH-olean-9,12-diene-2,3,30-trioic acid.
- Subjects
DIMETHYL sulfate; METHYL formate; OZONOLYSIS; ACIDS
- Publication
Chemistry of Natural Compounds, 2024, Vol 60, Issue 4, p657
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-024-04407-2