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- Title
Innovations in Early Lung Cancer Detection: Tracing the Evolution and Advancements in Screening.
- Authors
Cotton, Lindsey B.; Bach, Peter B.; Cisar, Chris; Schonewolf, Caitlin A.; Tennefoss, Demetria; Vachani, Anil; Carter-Bawa, Lisa; Zaidi, Ali H.
- Abstract
Lung cancer mortality rates, particularly non-small cell lung cancer (NSCLC), continue to present a significant global health challenge, and the adoption of lung cancer screening remains limited, often influenced by inequities in access to healthcare. Despite clinical evidence demonstrating the efficacy of annual screening with low-dose computed tomography (LDCT) and recommendations from medical organizations including the U.S. Preventive Services Task Force (USPSTF), the national lung cancer screening uptake remains around 5% among eligible individuals. Advancements in the clinical management of NSCLC have recently become more personalized with the implementation of blood-based biomarker testing. Extensive research into tumor-derived cell-free DNA (cfDNA) through fragmentation offers a novel method for improving early lung cancer detection. This review assesses the screening landscape, explores obstacles to lung cancer screening, and discusses how a plasma whole genome fragmentome test (pWGFrag-Lung) can improve lung cancer screening participation and adherence.
- Subjects
U.S. Preventive Services Task Force; NON-small-cell lung carcinoma; HEALTH equity; LUNG cancer; EARLY detection of cancer; COMPUTED tomography
- Publication
Journal of Clinical Medicine, 2024, Vol 13, Issue 16, p4911
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm13164911