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- Title
Antipsikotiklerin Güvenilirlik ve Tolerabilitesine Yeni Bir Yaklaşım.
- Authors
Gönül, Ali Saffet; Eker, Çağdaş; Şimşek, Fatma
- Abstract
Despite the intensive research in the field, antipsychotics with dopamine receptor blockers are mainstay of schizophrenia treatment. Although antipsychotic drugs are very effective for the treatment, they have side effects including extrapyramidal symptoms. Extrapyramidal system side effects are known by their motor system symptoms however, blocking extrpyramidal dopamine receptors also lead to affective symptoms. New atypical antipsychotics decreased the incidence of extrapyramidal side effects nevertheless; these symptoms are still the main reason for non adherence to antipsychotic treatment regime. Eventhough, paliperidone, is an active metabolite of risperidone, it has different pharmacokinetic and pharmacodynamic profiles compared to mother molecule. In placebo-controlled studies it has been shown that with a starting dose, 6 mg/day, paliperidone was tolerated verywell without increasing prolactine secretion, QTc prolongation and weight gain. It gives the impression that paliperidone is a good alternative for short and long-term treatment of schizophrenia. This impression needs to be supported with long-term treatment observations and studies.
- Subjects
ANTIPSYCHOTIC agents; SCHIZOPHRENIA treatment; DOPAMINE receptors; RISPERIDONE; WEIGHT gain
- Publication
Klinik Psikofarmakoloji Bulteni, 2009, Vol 19, Issue Supp 2, p326
- ISSN
1017-7833
- Publication type
Article