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- Title
Euterpe oleracea (Martius) Oil Reverses Testicular Alterations Caused after Cadmium Administration.
- Authors
Mouro, Viviane Gorete Silveira; de Melo, Fabiana Cristina Silveira Alves; Martins, Ana Luíza Pereira; de Lucca Moreira Gomes, Marcos; de Oliveira, Jerusa Maria; de Freitas, Mariella Bontempo Duca; Demuner, Antônio Jacinto; Leite, João Paulo Viana; da Matta, Sérgio Luis Pinto
- Abstract
Cadmium (Cd) is an environmental pollutant that induces reproductive toxicity by generating reactive oxygen species, which leads to oxidative stress. Euterpe oleracea fruits are known for being rich in oils containing triacylglycerol and phenolic compounds. They are considered as potent antioxidants to be used to counteract Cd effects within the testis. In the present study, adult males Swiss mice were treated with CdCl2 aqueous solution (4.28 mg/kg) by gavage for 7 days. The experimental groups were treated with Euterpe oleracea oil at the doses of 50, 100, and 150 mg/kg, for 42 days. The results showed that Cd intoxication led to increased tubular pathologies, such as reduction in epithelium height and area thus increasing both luminal diameter and tubule-epithelium ratio. Besides, Leydig cell's morphometry indicated reduction in nucleus and cytoplasm volumes of this cell type, which were recovered after E. oleracea oil intake. In addition, serum testosterone levels, testicular Mn and Zn concentrations, SOD and CAT activity, and germ cell viability increased after oil intake. Therefore, E. oleracea oil showed a regenerative effect in the testicular parenchyma negatively affected by Cd, mainly in the animals that received the highest oil concentration (150 mg/kg).
- Subjects
ACAI palm; REACTIVE oxygen species; LEYDIG cells; POLLUTANTS; DENTINAL tubules; SCROTUM
- Publication
Biological Trace Element Research, 2020, Vol 197, Issue 2, p555
- ISSN
0163-4984
- Publication type
Article
- DOI
10.1007/s12011-019-02004-x