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- Title
Long non-coding RNA ZFAS1 regulates the malignant progression of gastric cancer via the microRNA-200b-3p/Wnt1 axis.
- Authors
Zhang, Fan; Li, Ying; Xu, Weiran; He, Liang; Tan, Yan; Xu, Hong
- Abstract
Gastric cancer is a common malignant tumor. Studies from our laboratory or others have shown that long non-coding RNA (lncRNA) zinc finger antisense (ZFAS)1 often acts as an oncogene. However, the molecular underpinnings of how ZFAS1 regulates gastric cancer remain to be elucidated. Results showed that ZFAS1 expression was upregulated, and microRNA-200b-3p (miR-200b) expression was downregulated in gastric cancer tissues. MiR-200b overexpression suppressed the proliferation, cell cycle process, and Wnt/β-catenin signaling of gastric cancer cells. Subsequently, we identified miR-200b is a target of ZFAS1 and Wnt1 is a target of miR-200b. Furthermore, promotion of cancer malignant progression and activation of Wnt/β-catenin signaling induced by ZFAS1 was counteracted by increasing miR-200b expression. In vivo, ZFAS1 knockdown suppressed the tumorigenesis with the upregulated miR-200b and the inactive Wnt/β-catenin signaling. Summarily, we demonstrated a critical role of miR-200b in gastric cancer, and ZFAS1 can promote malignant progression through regulating miR-200b mediated Wnt/β-catenin signaling. In gastric cancer, miR-200b acts as an anti-tumor gene and ZFAS1 promotes malignant progression through regulating miR-200b mediated Wnt/β-catenin signaling.
- Subjects
NON-coding RNA; MICRORNA; ZINC-finger proteins
- Publication
Bioscience, Biotechnology & Biochemistry, 2019, Vol 83, Issue 7, p1289
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1080/09168451.2019.1606697