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- Title
Mulberry juice freeze-dried powder attenuates the disease severity by the maintaining of colon mucosa in mice with DSS-induced acute colitis.
- Authors
Wang, Yang; Hatabu, Toshimitsu
- Abstract
This study aimed to evaluate the microbial compositions and gene expression related to inflammation in dextran sodium sulfate (DSS)-induced acute colitis and the effect of mulberry supplementation. Male BALB/c mice received a diet supplemented with mulberry juice freeze-dried powder (MFP) or not for 3 weeks. After 3 weeks, the mice received water containing 5% (w/v) DSS or not for 1 week. The disease activity index score in mice fed MFP was significantly decreased. A significant decrease in Bifidobacterium spp. and the Clostridium perfringens subgroup was observed in mice not fed MFP. The number of goblet cell and NLRP6 expression were observed in mice fed a diet supplemented with MFP compared with mice not fed MFP. These results may indicate that mulberry mitigates DSS-induced acute colitis by a changing the gut microbial flora and by improving mucosal conditions. Mulberry fruit freeze-dried powder maintains the colonic microenvironment including bacterial balance in mice with DSS-induced acute colitis.
- Subjects
MULBERRY; SODIUM sulfate; EXFOLIATIVE cytology
- Publication
Bioscience, Biotechnology & Biochemistry, 2019, Vol 83, Issue 5, p914
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1080/09168451.2019.1580135