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- Title
Angiogenic Effects of Anxiolytic Fabomotizole.
- Authors
Kryzhanovskii, S. A.; Antipova, T. A.; Vititnova, M. B.; Nikolaev, S. V.; Durnev, A. D.
- Abstract
In vitro experiments performed on an isolated human endothelial HUVEC cell culture showed that the anxiolytic fabomotizole, which, in addition to the anxiolytic effect, has neuroprotective and cardioprotective activities largely associated with its agonistic action on sigma-1 receptors and shows a pronounced angiogenic activity. Fabomotizole angiogenic activity is realized in the range concentration from 10–5 to 10–8 M and is doze-dependent. In the literature, data on the presence of angiogenic activity in sigma receptor agonists have not been previously reported.
- Subjects
SIGMA receptors; ENDOTHELIAL cells; CELL culture
- Publication
Doklady Biochemistry & Biophysics, 2021, Vol 497, Issue 1, p63
- ISSN
1607-6729
- Publication type
Article
- DOI
10.1134/S1607672921020101