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- Title
A Nanoscale Metal–Organic Framework to Mediate Photodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Enhance Antigen Presentation and Cancer Immunotherapy.
- Authors
Ni, Kaiyuan; Luo, Taokun; Lan, Guangxu; Culbert, August; Song, Yang; Wu, Tong; Jiang, Xiaomin; Lin, Wenbin
- Abstract
Checkpoint blockade immunotherapy (CBI) awakes a host innate immune system and reactivates cytotoxic T cells to elicit durable response in some cancer patients. Now, a cationic nanoscale metal–organic framework, W‐TBP, is used to facilitate tumor antigen presentation by enabling immunogenic photodynamic therapy (PDT) and promoting the maturation of dendritic cells (DCs). Comprised of dinuclear WVI secondary building units and photosensitizing 5,10,15,20‐tetra(p‐benzoato)porphyrin (TBP) ligands, cationic W‐TBP mediates PDT to release tumor associated antigens and delivers immunostimulatory CpG oligodeoxynucleotides to DCs. The enhanced antigen presentation synergizes with CBI to expand and reinvigorate cytotoxic T cells, leading to superb anticancer efficacy and robust abscopal effects with >97 % tumor regression in a bilateral breast cancer model.
- Subjects
CPG nucleotides; ANTIGEN presentation; PHOTODYNAMIC therapy; METAL-organic frameworks; CYTOTOXIC T cells; METALLOPORPHYRINS; ANTIGEN presenting cells; DENDRITIC cells
- Publication
Angewandte Chemie, 2020, Vol 132, Issue 3, p1124
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201911429