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- Title
Intermolecular C−H Amidation of (Hetero)arenes to Produce Amides through Rhodium‐Catalyzed Carbonylation of Nitrene Intermediates.
- Authors
Yuan, Si‐Wen; Han, Hui; Li, Yan‐Lin; Wu, Xueli; Bao, Xiaoguang; Gu, Zheng‐Yang; Xia, Ji‐Bao
- Abstract
Amide bond formation is one of the most important reactions in organic chemistry because of the widespread presence of amides in pharmaceuticals and biologically active compounds. Existing methods for amides synthesis are reaching their inherent limits. Described herein is a novel rhodium‐catalyzed three‐component reaction to synthesize amides from organic azides, carbon monoxide, and (hetero)arenes via nitrene‐intermediates and direct C−H functionalization. Notably, the reaction proceeds in an intermolecular fashion with N2 as the only by‐product, and either directing groups nor additives are required. The computational and mechanistic studies show that the amides are formed via a key Rh‐nitrene intermediate.
- Subjects
AMIDATION; RHODIUM catalysts; CARBONYLATION; NITRENES; INTERMEDIATES (Chemistry); CARBON-hydrogen bonds
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 26, p8979
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201903656