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- Title
A Small-Molecule Probe for Selective Profiling and Imaging of Monoamine Oxidase B Activities in Models of Parkinson's Disease.
- Authors
Li, Lin; Zhang, Cheng ‐ Wu; Ge, Jingyan; Qian, Linghui; Chai, Bing ‐ Han; Zhu, Qing; Lee, Jun ‐ Seok; Lim, Kah ‐ Leong; Yao, Shao Q.
- Abstract
The design of the first dual-purpose activity-based probe of monoamine oxidase B (MAO-B) is reported. This probe is highly selective towards MAO-B, even at high MAO-A expression levels, and could sensitively report endogenous MAO-B activities by both in situ proteome profiling and live-cell bioimaging. With a built-in imaging module as part of the probe design, the probe was able to accomplish what all previously reported MAO-B imaging probes failed to do thus far: the live-cell imaging of MAO-B activities without encountering diffusion problems.
- Subjects
MONOAMINE oxidase; PROTEOMICS; SMALL molecules; CHEMICAL research
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 37, p10971
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201504441