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- Title
Reversibly Controlling Preferential Protein Adsorption on Bone Implants by Using an Applied Weak Potential as a Switch.
- Authors
Liao, Jingwen; Zhu, Ye; Zhou, Zhengnan; Chen, Junqi; Tan, Guoxin; Ning, Chengyun; Mao, Chuanbin
- Abstract
A facile method is needed to control the protein adsorption onto biomaterials, such as, bone implants. Herein we doped taurocholic acid (TCA), an amphiphilic biomolecule, into an array of 1D nano-architectured polypyrrole (NAPPy) on the implants. Doping TCA enabled the implant surface to show reversible wettability between 152° (superhydrophobic, switch-on state) and 55° (hydrophilic, switch-off state) in response to periodically switching two weak electrical potentials (+0.50 and −0.80 V as a switch-on and switch-off potential, respectively). The potential-switchable reversible wettability, arising from the potential-tunable orientation of the hydrophobic and hydrophilic face of TCA, led to potential-switchable preferential adsorption of proteins as well as cell adhesion and spreading. This potential-switchable strategy may open up a new avenue to control the biological activities on the implant surface.
- Subjects
PROTEIN research; BIOMOLECULES; ORGANIC compounds; ADSORPTION (Chemistry); SORPTION
- Publication
Angewandte Chemie, 2014, Vol 126, Issue 48, p13284
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201406349